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What are the common production equipment in the pharmaceutical industry
2024-09-09 14:11:42

制药行业常见生产设备有哪些

Pharmaceutical Manufacturing Equipment – Business Overview

 

1. Solid-Dosage Equipment

• Milling: particle-size reduction of APIs  

• Sieving & classification: consistent granule size  

• Granulators: wet or dry granulation for tablets/capsules  

• Dryers: ovens, fluid-bed dryers – moisture removal for stability  

• Tablet presses: compression of powders into tablets  

• Capsule fillers: powder/granule filling into hard/soft capsules  

• Coaters: film, sugar, or enteric coating for taste-masking or controlled release  

• Packaging lines: bottle, blister, sachet, stick-pack, cartoning, labeling, case-pack, serialization, printing

 

2. Liquid-Dosage Equipment

• Mixing & dissolving tanks for API and excipients  

• Bottle washers – glass vial cleaning for sterile liquids  

• BFS (blow-fill-seal) machines – aseptic filling and sealing  

• Sterilizers – terminal sterilization of finished liquids  

• End-of-line packaging (bottling, labeling, cartoning, serialization)

 

3. Sterile-Dosage Equipment

• Membrane & cartridge filtration – microbial and particulate removal  

• Purification systems – HPLC/GC for in-process control  

• Autoclaves / SIP systems – validated sterilization  

• Pre-filled syringe/fill-finish isolators – aseptic filling & stoppering  

• Freeze-dryers (lyophilizers) – conversion of liquids to sterile powders  

• Secondary packaging lines (same formats as above)

 

4. Biologics Equipment

• Synthesis reactors – raw-material preparation  

• Fermenters/bioreactors – microbial or mammalian cell culture  

• High-speed centrifuges – cell harvest & clarification  

• Lyophilizers – sterile bulk or vial freeze-drying  

• Final packaging lines (bottle, blister, sachet, cartoning, labeling, serialization)

 

5. API (Active Pharmaceutical Ingredient) Equipment

• Reactors, towers, kettles, pumps & tanks – chemical synthesis  

• Crystallizers – controlled crystal formation  

• Filter presses – solid-liquid separation post-crystallization  

• Dryers – vacuum or conical dryers for API stability  

• Vacuum systems – process-specific vacuum supply  

• Chiller loops – precise temperature control  

• Liquid fillers & solid packers – bulk API packaging

 

6. Traditional Chinese Medicine (TCM) Equipment

• Extractors – solvent or water extraction of botanical actives  

• Blending vessels – uniform mixing of herbal extracts  

• Pill/pellet machines – TCM pill forming  

• Spray dryers – liquid-to-powder conversion  

• Vacuum dryers – low-temperature drying of heat-sensitive TCM products  

• Final packaging lines (bottle, blister, sachet, cartoning, labeling, serialization)

 

7. Utility & Ancillary Equipment

• Chillers, air compressors, vacuum pumps – utilities for process support  

• HVAC & clean-room systems – temperature, humidity, particulate control  

• Dust collectors – airborne-particle containment  

• PSA nitrogen generators – inert-gas supply  

• Boilers – steam or hot-water generation  

• Piping, valves, instrumentation – fluid conveyance, control and monitoring

 

8. Infrastructure & Support Facilities

• Manufacturing buildings, QC labs, animal houses, warehouses, cold rooms, hazardous-material stores  

• Fire-pump stations – life-safety compliance  

• Electrical substations – reliable power supply  

• Wastewater-treatment plants – effluent compliance