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How valves should be selected in the pharmaceutical industry in general
2024-09-09 14:04:17

Pharmaceutical valves are designed to meet high hygienic requirements and are suitable for use in industries such as pharmaceutical and food processing.


The following table lists the advantages and disadvantages of valves commonly used in the pharmaceutical industry:



Valve Types

MeritShortcoming
Shut-off valves
  • ·It can be used at high frequency

  • Can be used for autoclaving

  • Good regulation performance

  • The pressure loss of the medium is large

  • The flow direction is fixed

  • Can only be used with clean and non-particulate media

Diaphragm valves
  • It can be used at high frequency

  • Clean media or contaminated media are acceptable

  • No dead ends

  • Sterilizable

  • Cleanable

  • Good regulation performance

  • Flow direction is optional

  • The pressure loss of the medium is large

  • Costs and maintenance costs are higher

  • There are limits to operating pressure and temperature

  • Wear out quickly

Butterfly valves
  • Low pressure loss

  • Flow direction is optional

  • Compact structure and light weight

  • The cost is relatively lo

  • The operating frequency is low

  • Relatively poor regulation performance

  • High wear rate (particulate media)

  • to lower working pressures

Ball valves
  • Low cost

  • Close tightly

  • Ball-through type with virtually no pressure loss

  • Flow direction is optional

  • It is suitable for high temperature and high pressure conditions

  • Low operating frequency

  • Relatively poor regulation performance

  • Large dead space when closed 


Under EU GMP guidelines, valves must prevent cross-contamination and be easy to clean. In practice, FDA-certified diaphragm valves are the specified choice for sterile applications, while FDA-certified globe valves are mandated for clean-room utilities. For sterile duties, FDA documentation explicitly requires diaphragm valves to guarantee effective cleanability. Non-product media such as cooling water or steam are handled by butterfly, ball or globe valves; since these fluids do not directly affect product quality, selection is driven primarily by cost considerations.

 

Source: Dandelion